LECCIÓN

1

MÓDULO

6

Investigación traslacional y biomarcadores emergentes en la enfermedad de Alzheimer
Dra. Estibaliz Capetillo González de Zárate

Departamento de Neurociencias, Facultad de Farmacia, Universidad del País Vasco/ Euskal Herriko Unibertsitatea (UPV/EHU), Leioa. Achucarro Basque Center for Neuroscience Fundazioa, Parque Científico UPV/EHU, Leioa

Referencias bibliográficas

  1. Selkoe DJ, Hardy J. The amyloid hypothesis of Alzheimer's disease at 25 years. EMBO Mol Med. 2016 Jun 1;8(6):595-608. [Pubmed]
  2. Mankhong S, Kim S, Lee S, Kwak HB, Park DH, Joa KL, Kang JH. Development of Alzheimer's Disease Biomarkers: From CSF- to Blood-Based Biomarkers. Biomedicines. 2022 Apr 5;10(4):850. [Pubmed]
  3. Jack CR Jr, Bennett DA, Blennow K, Carrillo MC, Dunn B, Haeberlein SB, et al.; Contributors. NIA-AA Research Framework: Toward a biological definition of Alzheimer's disease. Alzheimers Dement. 2018 Apr;14(4):535-62. [Pubmed]
  4. Teunissen CE, Verberk IMW, Thijssen EH, Vermunt L, Hansson O, Zetterberg H, et al. Blood-based biomarkers for Alzheimer's disease: towards clinical implementation. Lancet Neurol. 2022 Jan;21(1):66-77. [Pubmed]
  5. Pereira JB, Janelidze S, Stomrud E, Palmqvist S, van Westen D, Dage JL, et al. Plasma markers predict changes in amyloid, tau, atrophy and cognition in non-demented subjects. Brain. 2021 Oct 22;144(9):2826-36. [Pubmed]
  6. Palmqvist S, Janelidze S, Quiroz YT, Zetterberg H, Lopera F, Stomrud E, et al. Discriminative Accuracy of Plasma Phospho-tau217 for Alzheimer Disease vs Other Neurodegenerative Disorders. JAMA. 2020 Aug 25;324(8):772-81. [Pubmed]
  7. Shen XN, Huang YY, Chen SD, Guo Y, Tan L, Dong Q, Yu JT; Alzheimer’s Disease Neuroimaging Initiative. Plasma phosphorylated-tau181 as a predictive biomarker for Alzheimer's amyloid, tau and FDG PET status. Transl Psychiatry. 2021 Nov 13;11(1):585. [Pubmed]
  8. Tatebe H, Kasai T, Ohmichi T, Kishi Y, Kakeya T, Waragai M, et al. Quantification of plasma phosphorylated tau to use as a biomarker for brain Alzheimer pathology: pilot case-control studies including patients with Alzheimer's disease and down syndrome. Mol Neurodegener. 2017 Sep 4;12(1):63. [Pubmed]
  9. Brickman AM, Manly JJ, Honig LS, Sánchez D, Reyes-Dumeyer D, Lantigua RA, et al. Plasma p-tau181, p-tau217, and other blood-based Alzheimer's disease biomarkers in a multi-ethnic, community study. Alzheimers Dement. 2021 Aug;17(8):1353-64. [Pubmed]
  10. Carter SF, Herholz K, Rosa-Neto P, Pellerin L, Nordberg A, Zimmer ER. Astrocyte Biomarkers in Alzheimer's Disease. Trends Mol Med. 2019 Feb;25(2):77-95. [Pubmed]
  11. Ferrari-Souza JP, Ferreira PCL, Bellaver B, Tissot C, Wang YT, Leffa DT, et al. Astrocyte biomarker signatures of amyloid-β and tau pathologies in Alzheimer's disease. Mol Psychiatry. 2022 Nov;27(11):4781-9. [Pubmed]
  12. Zhang PF, Hu H, Tan L, Yu JT. Microglia Biomarkers in Alzheimer's Disease. Mol Neurobiol. 2021 Jul;58(7):3388-404. [Pubmed]
  13. Camporesi E, Nilsson J, Brinkmalm A, Becker B, Ashton NJ, Blennow K, Zetterberg H. Fluid Biomarkers for Synaptic Dysfunction and Loss. Biomark Insights. 2020 Aug 21;15:1177271920950319. [Pubmed]
  14. Walgrave H, Zhou L, De Strooper B, Salta E. The promise of microRNA-based therapies in Alzheimer's disease: challenges and perspectives. Mol Neurodegener. 2021 Nov 6;16(1):76. [Pubmed]
  15. Xing W, Gao W, Lv X, Xu X, Zhang Z, Yan J, et al. The Diagnostic Value of Exosome-Derived Biomarkers in Alzheimer's Disease and Mild Cognitive Impairment: A Meta-Analysis. Front Aging Neurosci. 2021 Mar 1;13:637218. [Pubmed]
  16. Vaz M, Soares Martins T, Henriques AG. Extracellular vesicles in the study of Alzheimer's and Parkinson's diseases: Methodologies applied from cells to biofluids. J Neurochem. 2022 Nov;163(4):266-309. [Pubmed]
  17. Yin F. Lipid metabolism and Alzheimer's disease: clinical evidence, mechanistic link and therapeutic promise. FEBS J. 2023 Mar;290(6):1420-53. [Pubmed]
  18. Kang JH, Korecka M, Figurski MJ, Toledo JB, Blennow K, Zetterberg H, et al.; Alzheimer's Disease Neuroimaging Initiative. The Alzheimer's Disease Neuroimaging Initiative 2 Biomarker Core: A review of progress and plans. Alzheimers Dement. 2015 Jul;11(7):772-91. [Pubmed]
  19. Suárez-Calvet M, Kleinberger G, Araque Caballero MÁ, Brendel M, Rominger A, Alcolea D, et al. sTREM2 cerebrospinal fluid levels are a potential biomarker for microglia activity in early-stage Alzheimer's disease and associate with neuronal injury markers. EMBO Mol Med. 2016 May 2;8(5):466-76. [Pubmed]